For patients with
connective
tissue disease
Make the Connection
A rare disease.
A serious
complication.1
Help identify patients with systemic sclerosis (SSc) who should be evaluated for PAH
Make the Connection Between PAH and CTD
CTD=connective tissue disease; ERS=European
Respiratory Society; ESC=European Society of Cardiology; PAH=pulmonary arterial
hypertension; PAH-CTD=PAH associated with CTD;
SSc=systemic sclerosis.
References:
1. Zanatta E, Polito P, Famoso G, et al.
Pulmonary arterial hypertension in connective tissue disorders: pathophysiology and
treatment. Exp Biol Med. 2019;244(2):120-131.
2. Chung L, Farber HW, Benza R, et al.
Unique predictors of mortality in patients with pulmonary arterial hypertension
associated with systemic sclerosis in the REVEAL registry. CHEST.
2014;146(6):1494-1504. 3. Humbert M, Kovacs G, Hoeper MM, et
al; ESC/ERS Scientific Document Group. 2022 ESC/ERS Guidelines for the diagnosis and
treatment of pulmonary hypertension: the Task Force for the Diagnosis and Treatment
of Pulmonary Hypertension of the European Society of Cardiology (ESC) and the
European Respiratory Society (ERS). Eur Heart J. 2022;43(38):3618-3731.
4. Coghlan JG, Denton CP, Grünig E,
et al; DETECT study group. Evidence-based detection of pulmonary arterial
hypertension in systemic sclerosis: the DETECT study. Ann Rheum Dis.
2014;73(7):1340-1349. 5. Minai OA, Budev MM.
Diagnostic strategies for suspected pulmonary arterial hypertension: a primer for
the internist. Cleve Clin J Med. 2007;74(10):737-747.
6. McLaughlin VV, Shah SJ, Souza R,
Humbert M. Management of pulmonary arterial hypertension. J Am Coll
Cardiol. 2015;65(18):1976-1997.
